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Indinavir sulfate
CAS No. 157810-81-6
Indinavir sulfate ( MK-639 sulfate | L735524 sulfate )
产品货号. M20547 CAS No. 157810-81-6
Indinavir 是一种 HIV 蛋白酶抑制剂。它抑制 HIV-1 蛋白酶，IC50 值为 0.41 nM，Ki 值为 0.24 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 50MG | ￥389 | 有现货 |
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| 100MG | ￥640 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Indinavir sulfate
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Indinavir 是一种 HIV 蛋白酶抑制剂。它抑制 HIV-1 蛋白酶，IC50 值为 0.41 nM，Ki 值为 0.24 nM。
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产品描述Indinavir is a HIV protease inhibitor.It inhibits the HIV-1 protease with an IC50 value of 0.41 nM and Ki value of 0.24 nM.
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体外实验Cell Viability Assay Cell Line:PBMCs (from healthy and HIV-infected volunteers)Concentration:0-50 μMIncubation Time:18 h (pretreatment; stimulation with anti-CD3 for an additional 48 hours)Result:Blocked anti-CD3-induced cell-cycle progression in a dose-dependent manner.Resulted in dose-dependent reduction of lymphoproliferative responses.Cell Invasion Assay Cell Line:Huh7 and SK-HEP-1 cells Concentration:40 μM-40 nM Incubation Time:5 days Result:Reduced ability to invade an in vitro constituted extracellular matrix for both cell lines treated compared with the untreated cells.Western Blot Analysis Cell Line:Huh7 and SK-HEP-1 cells Concentration:40 μM-40 nM Incubation Time:48 h Result:Blocked the conversion of latent MMP-2 to its 62/64-kDa active form.
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体内实验Animal Model:Nude mice(s.c. into Huh7 and SK-HEP-1 cells).Dosage:70 mg/kg Administration:Oral gavage; once a day for 3 weeks. Result:Delaied the growth of s.c. implanted hepatocarcinoma xenografts in nude mice compared with placebo.
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同义词MK-639 sulfate | L735524 sulfate
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通路Microbiology/Virology
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靶点HIV
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受体HIV Protease
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研究领域Inflammation/Immunology
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适应症HIV infection.
化学信息
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CAS Number157810-81-6
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分子量711.87
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分子式C36H49N5O8S
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纯度>98% (HPLC)
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溶解度DMSO:100 mg/mL (140.48 mM)
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SMILESOS(O)(=O)=O.CC(C)(C)NC(=O)C1CN(Cc2cccnc2)CCN1CC(O)CC(Cc1ccccc1)C(=O)NC1C(O)Cc2ccccc12
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化学全称(S)-1-((2S4R)-4-benzyl-2-hydroxy-5-(((1S2R)-2-hydroxy-23-dihydro-1H-inden-1-yl)amino)-5-oxopentyl)-N-(tert-butyl)-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide sulfate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Ekins S Mathews P Saito E K et al. α7-Nicotinic acetylcholine receptor inhibition by indinavir: implications for cognitive dysfunction in treated HIV disease[J]. AIDS (London England) 2017 31(8).
